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CONTENTS

CHAPTER 1 INTRODUCTION 1

SECTION 1 A BRIEF HISTORY 1

SECTION 2 MOLECULAR BIOLOGY PROMOTE MEDICINE TO THE MOLECULAR LEVEL 11

CHAPTER 2 THE MOLECULAR NATURE OF GENES 16

SECTION 1 THE NATURE OF GENETIC MATERIAL 16

SECTION 2 STRUCTURE OF NUCLEIC ACIDS 21

SECTION 3 NUCLEOSOME AND CHROMATIN ASSEMBLY 27

SECTION 4 PHYSICAL CHEMISTRY OF NUCLEIC ACIDS 35

CHAPTER 3 NATURE AND FUNCTION OF GENES 42

SECTION 1 THE NATURE OF GENES 42

SECTION 2 PROTEIN STRUCTURE AND FUNCTION 43

SECTION 3 OVERVIEW OF GENE EXPRESSION 49

SECTION 4 REPLICATION 57

SECTION 5 MUTATIONS 58

CHAPTER 4 DNA REPLICATION OF PROKARYOTES 62

SECTION 1 GENERAL FEATURES OF PROKARYOTIC DNA REPLICATION 62

SECTION 2 ENZYMOLOGY OF PROKARYOTIC DNA REPLICATION 69

SECTION 3 DETAILED PROCEDURES OF PROKARYOTIC DNA REPLICATION 79

CHAPTER 5 DNA REPLICATION OF EUKARYOTES 92

SECTION 1 FEATURES OF EUKARYOTIC DNA REPLICATION SYSTEM 92

SECTION 2 DETAILED PROCEDURES OF EUKARYOTIC DNA REPLICATION 103

SECTION 3 TELOMERES AND CANCER 109

CHAPTER 6 DNA DAMAGE AND REPAIR 111

SECTION 1 POLYMORPHISM AND MUTATION OF GENETIC MATERIALS 111

SECTION 2 DNA DAMAGE 112

SECTION 3 DNA REPAIR 115

SECTION 4 OUTE OF FAILURE TO REPAIR THE DAMAGED DNA 125

CHAPTER 7 TRANSCRIPTION IN PROKARYOTES 130

SECTION 1 PONENTS OF THE PROKARYOTIC TRANSCRIPTION SYSTEM 130

SECTION 2 PROCESS OF THE PROKARYOTIC TRANSCRIPTION 133

CHAPTER 8 REGULATION OF PROKARYOTIC TRANSCRIPTION 142

SECTION 1 GENERAL CONSIDERATIONS ON PROTEIN–DNA INTERACTION 142

SECTION 2 OPERONS: FINE CONTROL OF BACTERIAL TRANSCRIPTION 143

CHAPTER 9 TRANSCRIPTION IN EUKARYOTES 164

SECTION 1 THE EUKARYOTIC TRANSCRIPTION SYSTEM 164

SECTION 2 PROCESS OF THE EUKARYOTIC TRANSCRIPTION 179

CHAPTER 10 REGULATION OF TRANSCRIPTION IN EUKARYOTES 193

SECTION 1 TRANSCRIPTIONAL ACTIVATORS: DEFINITION， CATEGORIES AND MECHANISMS 193

SECTION 2 TRANSCRIPTIONAL REPRESSORS 212

SECTION 3 CHROMATIN REMODELING AND TRANSCRIPTION 213

SECTION 4 REGULATION OF TRANSCRIPTION FACTORS 223

SECTION 5 TRANSCRIPTIONAL COACTIVATORS AND COREPRESSORS 224

SECTION 6 SIGNALING PATHWAYS THAT REGULATE TRANSCRIPTION 230

CHAPTER 11 POST-TRANSCRIPTIONAL EVENTS AND REGULATION 238

SECTION 1 RNA SPLICING 238

SECTION 2 CAPPING AND POLYADENYLATION 250

SECTION 3 OTHER POST-TRANSCRIPTIONAL MECHANISMS OF MRNA REGULATION 260

SECTION 4 PROCESSING EVENTS OF OTHER RNAS 269

CHAPTER 12 TRANSLATION 276

SECTION 1 THE CELLULAR APARATUS FOR TRANSLATION 276

SECTION 2 INITIATION OF TRANSLATION 291

SECTION 3 ELONGATION AND TERMINATION OF TRANSLATION 306

CHAPTER 13 POST-TRANSLATIONAL EVENTS 323

SECTION 1 POST-TRANSLATIONAL PROCESSING AND PROTEIN TRAFFICKING 323

SECTION 2 SITE-SPECIFIC MODIFICATION OF PROTEINS 329

SECTION 3 PROTEIN DEGRADATION 336

CHAPTER 14 DNA REBINATION， TRANSPOSITION & EDITING 341

SECTION 1 THE HOMOLOGOUS REBINATION 342

SECTION 2 TRANSPOSITION 348

SECTION 3 GENE EDITING 358

CHAPTER 15 ONCOGENES AND TUMOR SUPPRESSOR GENES 362

SECTION 1 ONCOGENES 362

SECTION 2 TUMOR SUPPRESSOR GENES 372

SECTION 3 COLLABORATIONS OF ONCOGENES AND TUMOR-SUPPRESSOR GENES IN TUMORIGENESIS 381

CHAPTER 16 MOLECULAR CLONING METHODS 384

SECTION 1 GENE CLONING 384

SECTION 2 THE POLYMERASE CHAIN REACTION 396

SECTION 3 EXPRESSING CLONED GENES 398

CHAPTER 17 METHODS FOR STUDYING GENE FUNCTION 403

SECTION 1 MOLECULAR SEPARATIONS 403

SECTION 2 MOLECULAR TOOLS FOR IDENTIFYING GENES 408

SECTION 3 ASSAYING GENE AND GENE PRODUCT INTERACTIONS 422

SECTION 4 ANALYZING GENE FUNCTION IN THE ORGANISM 429

CHAPTER 18 IDENTIFICATION OF DISEASE-RELATED GENES 434

SECTION 1 A ROUTE MAP FOR IDENTIFYING DISEASE GENES 434

SECTION 2 CHROMOSOMAL POSITIONAL CLONING OF DISEASE GENES 434

SECTION 3 CLONING DISEASE GENES INDEPENDENTLY OF THEIR CHROMOSOMAL POSITION 443

SECTION 4 MODELS FOR CLONING DISEASE-RELATED GENES 446

SECTION 5 FUNCTIONAL VALIDATION OF DISEASE GENES 446

CHAPTER 19 GENE DIAGNOSIS 448

SECTION 1 THE CONCEPT AND CHARACTERISTICS OF GENE DIAGNOSIS 448

SECTION 2 THE BASIC TECHNIQUES IN GENE DIAGNOSIS 449

SECTION 3 THE MEDICAL APPLICATION OF GENE DIAGNOSIS 454

CHAPTER GENE THERAPY 459

SECTION 1 STRATEGIES OF GENE THERAPY 459

SECTION 2 PROCEDURES FOR GENE THERAPY 460

SECTION 3 CLINICAL PRACTICE OF GENE THERAPY 477

CHAPTER 21 GENOMICS AND POST-GENOMICS 484

SECTION 1 TECHNIQUES IN GENOMIC SEQUENCING 484

SECTION 2 STUDYING AND PARING GENOMIC SEQUENCES 491

SECTION 3 TRANSCRIPTOMICS 497

SECTION 4 PROTEOMICS 503

SECTION 5 OTHER MOLECULAR OMICS STUDY 511

SECTION 6 BIOINFORMATICS 512

INDEX 517

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